Seropositivity of samples included in analysis in study of SARS-CoV-2 seroprevalence and immunity in cats, United Kingdom, April 2020–February 2022. The University of Glasgow Veterinary Ethics Committee granted approval for the study (EA27/20).įigure 1. We measured neutralizing titers against a panel of viral pseudotypes based on a lentiviral (HIV) backbone and bearing the S proteins of the predominant circulating variants in the United Kingdom to investigate the specificity of the neutralizing response. We used a pseudotype-based neutralization assay (PTNA) to measure virus neutralizing antibody titers and a confirmatory ELISA that measured antibodies recognizing the receptor binding domain of the SARS-CoV-2 spike (S) protein. The aim of this study was to assess the seroprevalence of SARS-CoV-2 infection in cats during April 2020–February 2022 in the United Kingdom.
It is unknown whether individual SARS-CoV-2 variants are more or less likely to be transmitted from humans to cats or whether infected cats are more or less likely to develop clinical signs. There have also been reports of animal-to-human transmission of SARS-CoV-2 from farmed mink ( 2), pet hamsters ( 5), free-ranging white-tailed deer ( 6), and a pet cat ( 7). Animal SARS-CoV-2 infections originating from anthropogenic transmission can lead to onward animal-to-animal transmission, as described previously in mink ( 2), hamsters ( 3), and white-tailed deer ( 4).
The World Organisation for Animal Health reported that 26 different animal species had been infected with SARS-CoV-2 by Decem≈30% (8/26) of the susceptible species are felids ( 1).
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